Not within the same Smart Proxy. You can deploy multiple Smart Proxies to work around this.
The reason is that on the Foreman there is no tracking of providers (it’s fully transparent) and on the Smart Proxy side there’s no support for multiple providers with some routing.
The current route53 provider doesn’t support this. Since you can’t load multiple providers, the workaround here is to also run multiple Smart Proxies.
In theory you could run multiple Smart Proxies on the same machine, but there’s no out of the box support for it.